<scp>METTL3</scp> ‐Mediated <scp>m6A</scp> Modification Facilitates pri‐ <scp>miR</scp> ‐221 Maturation to Regulate Macrophage <scp>M1</scp> / <scp>M2</scp> Polarisation and Immune Inflammation in Rheumatoid Arthritis
METTL3 knockdown suppresses m6A-dependent pri-miR-221 maturation, rebalancing macrophage polarisation and attenuating ankle joint destruction in RA.
Authors
- Wei Li (ORCID: https://orcid.org/0000-0002-1924-3120)
- Xiaohui Wu
- Xiangping Gong
- Lirong Mao
Institutions
- Fourth Hospital of Changsha (CN)
- Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical and Experimental Pharmacology and Physiology
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/1440-1681.70099
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81