Claudin‐18 expression in gastric type adenocarcinoma and <scp>HPV</scp> ‐associated adenocarcinoma of the uterine cervix
CLDN18 (43-14A) emerged as a potential diagnostic and therapeutic marker for GAS. A minor subset of HPV-associated ECAs also can be immunoreactive for CLDN18 and express CLDN18.2 mRNA, suggesting divergent gastric phenotypic differentiation. The caution is that GAS and HPV-associated ECAs can share overlapping histological features and similar expression of CLDN18 and p16.
Authors
- Shinichiro Kawatoko (ORCID: https://orcid.org/0000-0001-5811-4834)
- Kiyoko Kato (ORCID: https://orcid.org/0000-0003-0047-7637)
- Ryosuke Kuga (ORCID: https://orcid.org/0009-0007-5369-4615)
- Nobuko Yasutake (ORCID: https://orcid.org/0000-0003-3092-969X)
- Rina Jiromaru (ORCID: https://orcid.org/0000-0002-3826-6870)
- Takehiro Tanaka (ORCID: https://orcid.org/0000-0002-1509-5706)
- Hidetaka Yamamoto
- Kenzo Sonoda
- Hideaki Yahata
- Yuki Yokawa
- Riri Mishima
- Yoshinao Oda
- Misato Komamizu (ORCID: https://orcid.org/0009-0003-8170-2660)
Institutions
- Kyushu University (JP)
- Okayama University (JP)
- Kyushu University Beppu Hospital (JP)
Publication Details
- Journal
- Histopathology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1111/his.70066
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00