Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice
Collectively, our data reveal a novel role for IAPP aggregates in decreasing MHCII antigen presentation and show that despite the well-established proinflammatory response of macrophages to IAPP aggregates, the uptake of IAPP aggregates during early amyloid formation also disrupts beta cell autoimmunity and delays diabetes in NOD mice.
Authors
- Mitsuhiro Komba (ORCID: https://orcid.org/0000-0001-7485-1746)
- Jane Velghe (ORCID: https://orcid.org/0000-0003-0830-9750)
- Imelda W. Suen
- Sam Chen
- Heather C. Denroche (ORCID: https://orcid.org/0000-0002-0976-2656)
- Galina Soukhatcheva (ORCID: https://orcid.org/0000-0002-5021-4037)
- Dominika Nąckiewicz (ORCID: https://orcid.org/0000-0001-5836-8789)
- Liam Stanley
- Derek L. Dai
- Victoria Ng
- C. Bruce Verchere
Institutions
- University of British Columbia (CA)
- Nanotherapeutics (United States) (US)
- BC Children's Hospital (CA)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1007/s00125-025-06622-0
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00