Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression

Combining bulk and spatial RNA-seq, this study characterized the molecular and immunological hallmarks of EGFR-mutated LUAD in the context of PD-L1 expression, providing new insights into the development of tailored therapeutic strategies for EGFR-mutated LUAD with high PD-L1 expression.

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Publication Details

Journal
Cellular Oncology
Published
2025-12-22
DOI
https://doi.org/10.1007/s13402-025-01143-9
Citations
1
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
1.52
Controls
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article

Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression

Xianling Zhang, Zhe Lei, SongBai Liu, Zaixiang Tang et al.
1 citations
Cellular Oncology
Lung Cancer Treatments and Mutations
1.52
article

Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression

Xianling Zhang, Zhe Lei, SongBai Liu, Zaixiang Tang, Ruyi Ma, Na Li, Hao Zhou, Chenxi Yu, Hualong Qin, Chenxi Shi
article en
1 citations

Abstract

Combining bulk and spatial RNA-seq, this study characterized the molecular and immunological hallmarks of EGFR-mutated LUAD in the context of PD-L1 expression, providing new insights into the development of tailored therapeutic strategies for EGFR-mutated LUAD with high PD-L1 expression.

Cellular OncologyVol. 49(1)
Chinese University of Hong Kong (HK), Soochow University (CN), Suzhou Vocational Health College (CN), First Affiliated Hospital of Soochow University (CN)
Good health and well-being
Openalex Percentile: Top 12%
Lung Cancer Treatments and Mutations
1.52
DOIOpen Access PDFOpenAlex
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