A Lipid Road to Neuroimmunology: Fatty Acids Linking Immune and Nervous Systems
Fatty acid receptors act as essential molecular sensors, connecting lipid signaling to both immune and neural outcomes, and their activation or inhibition influences cytokine production and neuron survival. Due to their role in these pathways, targeting fatty acid interactions to control inflammation and promote neural repair represents a promising strategy for neurological disease therapies. This review examines how fatty acids influence neuroimmune cells and may pave the way for the development of new therapeutic approaches.
Authors
- Cassiano Felippe Gonçalves-de-Albuquerque (ORCID: https://orcid.org/0000-0002-4458-3055)
- Francisco da Silva dos Santos
- Bárbara Albuquerque Carpinter (ORCID: https://orcid.org/0000-0001-8672-4461)
- Carolina Medina Coeli da Cunha
- Bianca Portugal Tavares de Moraes (ORCID: https://orcid.org/0000-0003-1524-2873)
- Adriana Ribeiro Silva (ORCID: https://orcid.org/0000-0002-5137-4251)
- Isabelle Moraes-de-Souza
- RENAN MUNIZ-SANTOS
- Marina Ferreira-Costa
- Gabrielle Lacerda de Souza Gomes-Reis
- Juliana Santiago Guedes Saraiva
Institutions
- Universidade Federal Fluminense (BR)
- Hospital Universitário Gaffrée e Guinle (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- NeuroImmunoModulation
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1159/000550168
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Universidade Federal Fluminense
- Universidade Federal do Estado do Rio de Janeiro