Senescent Cell Clearance Ameliorates Temporal Lobe Epilepsy and Associated Spatial Memory Deficits in Mice
Our data demonstrate that SCs accumulate in both human TLE and in a mouse model of TLE and suggest that clearing SCs may be a viable strategy to reduce seizures and associated cognitive comorbidities. ANN NEUROL 2026;99:1059-1075.
Authors
- Michelle Cho
- Tahiyana Khan (ORCID: https://orcid.org/0000-0003-1133-1334)
- Patrick Alexander Forcelli (ORCID: https://orcid.org/0000-0003-1763-060X)
- David McFall (ORCID: https://orcid.org/0009-0007-2359-2810)
- Timothy P. Casilli
- Logan A. Frayser
- Stefano Vicini (ORCID: https://orcid.org/0000-0002-1264-4896)
- Meaghan C. Steck
- Noah M. Kuehn
- Brent T. Harris
- Abbas I. Hussain
- Jacqueline A. Barnes
- Irene Sanchez‐Brualla
Institutions
- Georgetown University (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1002/ana.78118
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00