Potential value of m6A-related lncRNAs in diagnosis and therapy of pancreatic cancer

Pancreatic cancer is one of the digestive tract malignancies, and five-year overall survival rate of PAAD patients remains low. m6A can modify lncRNAs that could affect cancer cell proliferation and migration, it is of great significance to explore the mechanism of m6A-related lncRNA in the development of pancreatic cancer. In our study, 130 lncRNAs with a co-expression relationship with m6A genes were obtained by TCGA dataset analysis. A new prognostic model was constructed to predict overall survival in pancreatic cancer patients. Kaplan-Meier analysis, principalcomponent analysis (PCA), functional enrichment annotation, and nomogram were used to analyze the risk model. In addition, the relationship with the response to immunotherapy was explored. Finally, therapeutic agents targeting m6A-related lncRNA action targets were screened using the drug sensitivity database. In conclusion, our study highlighted the prognostic value of m6A-related lncRNAs in pancreatic cancer. We constructed a predictive model with high prognostic value and showed sensitivity in identifying patients with pancreatic cancer who may respond well to immunotherapy.