HELLP syndrome as a major contributor to adverse maternal and neonatal outcomes among preeclamptic women: findings from a multicenter retrospective cohort study
HELLP syndrome significantly worsens maternal and neonatal outcomes in preeclampsia, reflecting a need for improved early detection of 'high-risk' preeclamptic women like sFlt1/PLGF ratio and perhaps other laboratory tests like haptoglobin and D-dimer's. Many of these laboratory tests are currently not accessible in the Indonesian public health sector. Further research is needed to identify other markers that would assist in a more timely diagnosis of impending HELLP syndrome, particularly in early-onset preeclampsia patients managed conservatively.
Authors
- Anak Agung Gede Putra Wiradyana
- Maisuri T. Chalid (ORCID: https://orcid.org/0000-0001-8790-4915)
- Rima Irwinda (ORCID: https://orcid.org/0000-0002-6260-6273)
- Nuswil Bernolian (ORCID: https://orcid.org/0000-0002-5778-0074)
- Nutria Widya Purna Anggraini (ORCID: https://orcid.org/0000-0001-7652-1038)
- Ernawati Ernawati (ORCID: https://orcid.org/0000-0002-9188-9102)
- Dhanny Primatara Johari Santoso
- Muhammad A. Bachnas
- Julian Dewantiningrum
- Gustaaf Dekker
- Yusrawati
- Defrin
- Aditiawarman
- Bambang Rahardjo
- Muhammad I. A. Akbar
- Rozi Aditya Aryananda
Institutions
- Diponegoro University (ID)
- Universitas Airlangga (ID)
- Erasmus MC (NL)
- University of Indonesia (ID)
- Universitas Dr. Soetomo (ID)
- Universitas Muhammadiyah Palembang (ID)
- Broward Health (US)
- The University of Adelaide (AU)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12884-025-08600-1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00