In vivo real-time monitoring of tissue perfusion via L-lactate levels in interstitial fluid: an innovative and portable microfluidic device trial using a pig model
This approach demonstrated highly selective, sensitive, and robust detection of lactate in a clinical environment, with a microfluidics-powered instrument. We expect that this strategy can be used in the future as a tool for time-resolved biomarkers monitoring for bedside postoperative care.
Authors
- Xinne Zhao (ORCID: https://orcid.org/0000-0001-5478-6115)
- Martin Mirus (ORCID: https://orcid.org/0000-0001-8494-1403)
- Rebecca Bockholt
- Larysa Baraban (ORCID: https://orcid.org/0000-0003-1010-2791)
- Tom Alexander Schröder (ORCID: https://orcid.org/0009-0001-9689-3020)
- Željko Janićijević (ORCID: https://orcid.org/0000-0002-9494-9529)
- Peter Spieth (ORCID: https://orcid.org/0000-0003-3953-3253)
- Lars Heubner (ORCID: https://orcid.org/0000-0003-0522-564X)
- Günter Lauer
- Paula Korn
- Johanna Melius
Institutions
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1097/js9.0000000000003263
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00