Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis
Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.
Authors
- Dara Fonseca Balladares
- Kurt R. Stenmark (ORCID: https://orcid.org/0000-0001-6918-6411)
- Jane C. Kabwe
- David Irwin (ORCID: https://orcid.org/0000-0002-1743-8266)
- Michael H. Lee (ORCID: https://orcid.org/0000-0002-5739-8369)
- Linda Sanders
- Edford Sinkala (ORCID: https://orcid.org/0000-0002-5678-4540)
- Taonga Musonda (ORCID: https://orcid.org/0009-0008-9533-448X)
- Joan F. Hilton (ORCID: https://orcid.org/0000-0003-2452-4274)
- Kevin Nolan
- Claudia Silva Mickael (ORCID: https://orcid.org/0000-0002-1064-311X)
- Paul W. Buehler (ORCID: https://orcid.org/0000-0003-0687-3008)
- Katie Tuscan
- Brian B. Graham
- Rahul Kumar
- Joseph Phiri
- Sula Mazimba
- Annika S. Bai
Institutions
- University of Maryland, Baltimore (US)
- San Francisco General Hospital (US)
- University of California, San Francisco (US)
- University of Lusaka (ZM)
- AdventHealth Orlando (US)
- University Teaching Hospital (ZM)
- University of California System (US)
- National HIV/AIDS/STI/TB Council (ZM)
- National Institute of Public Administration (ZM)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Pulmonary Circulation
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/pul2.70230
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- American Heart Association
- United Therapeutics Corporation
- National Institutes of Health
- University of California, San Francisco
- National Institute of Allergy and Infectious Diseases