Effect of TGFβ–ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer

The TGFβ-ITGB6 positive feedback axis plays a critical role in liver metastasis of SMAD4 WT PC, highlighting ITGB6 as a potential therapeutic target, especially for patients with intact SMAD4 function.

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Publication Details

Journal
Chinese Medical Journal
Published
2025-12-17
DOI
https://doi.org/10.1097/cm9.0000000000003722
Primary Topic
TGF-β signaling in diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Effect of TGFβ–ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer

Bangbo Zhao, Yutong Zhao, Tianyu Li, Zeru Li et al.
Chinese Medical Journal
TGF-β signaling in diseases
article

Effect of TGFβ–ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer

Bangbo Zhao, Yutong Zhao, Tianyu Li, Zeru Li, Cheng Qin, Weibin Wang
article en

Abstract

The TGFβ-ITGB6 positive feedback axis plays a critical role in liver metastasis of SMAD4 WT PC, highlighting ITGB6 as a potential therapeutic target, especially for patients with intact SMAD4 function.

Chinese Medical Journal
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN)
Openalex Percentile: Top 37%
TGF-β signaling in diseases
DOIOpen Access PDFOpenAlex
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Effect of TGFβ–ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer — Bangbo Zhao, Yutong Zhao, et al. · Chinese Medical Journal (2025) | TGRS Research Map | TGRS