UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop

In conclusion, the UBE2K/CREB1 positive feedback loop promotes the development of BC, indicating that UBE2K could be a viable therapeutic target for anti-BC.

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Publication Details

Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Published
2025-12-21
DOI
https://doi.org/10.1016/j.bbadis.2025.168145
Primary Topic
Ubiquitin and proteasome pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop

Xiaozhen J. Liu, Qiuran Xu, HU Xiaoge, Jiancheng Mou et al.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Ubiquitin and proteasome pathways
article

UBE2K promotes breast cancer growth by ubiquitinating and degrading STUB1 to regulate the PKA/CREB1 signaling pathway, forming a feedback loop

Xiaozhen J. Liu, Qiuran Xu, HU Xiaoge, Jiancheng Mou, Da Qian, Hongchao Tang, Qinghui Zheng, Shuyan Liu, Xuli Meng, Mingxing Xu, Chenhong Li, Haotian Liu, Zhihao Ye, Zhuotao Yang, Haotian Su, Xin Zeng
article en

Abstract

In conclusion, the UBE2K/CREB1 positive feedback loop promotes the development of BC, indicating that UBE2K could be a viable therapeutic target for anti-BC.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseVol. 1872(3)
Soochow University (CN), Zhejiang Cancer Hospital (CN), Changshu No.1 People's Hospital (CN), Zhejiang Provincial People's Hospital (CN), Hangzhou Medical College (CN)
Good health and well-being
Openalex Percentile: Top 37%
Ubiquitin and proteasome pathways
DOIOpen Access PDFOpenAlex
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