pVHL status in clear cell renal cell carcinoma regulates HIF-α and E-cadherin expression levels and their implications for tumor progression
VHL inactivation causes HIF-α activation and suppresses E-cadherin expression, thereby promoting ccRCC progression. This study provides insights into the potential biomarkers and therapeutic targets for ccRCC treatment.
Authors
- Raviprakash T. Sitaram (ORCID: https://orcid.org/0000-0002-2391-5903)
- Börje Ljungberg
Institutions
- Umeå University (SE)
Publication Details
- Journal
- Upsala Journal of Medical Sciences
- Published
- 2025-12-22
- DOI
- https://doi.org/10.48101/ujms.v130.12982
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Umeå Universitet
- Cancerforskningsfonden i Norrland