Features of Mitochondrial Dynamics in Different Brain Parts of Patients with Alzheimer’s Disease

A number of recent studies have demonstrated the importance of investigating mitochondrial dynamics mechanisms in Alzheimer's disease (AD). This study involved an immunohistochemical analysis of mitochondrial dynamics markers Opa-1, Mfn-2, and Drp-1 in neurons of the middle frontal gyrus, anterior cingulate gyrus, head of the caudate nucleus, hippocampus, and inferior parietal lobule using autopsy material from AD patients. The comparison was made with similar brain regions in autopsy material from elderly and young patients. Additionally, changes in these markers in AD were correlated with the distribution of pathological amyloid aggregates in the corresponding regions. Our findings suggest specific features of metabolic process alterations in neurons in AD, which are not limited to a single brain region but involve multiple areas and exhibit a uniform pattern. Our data are significant for understanding the pathogenesis of this disease and aging in general, and may serve as a basis for developing targeted therapy for AD.