Utility of the Amygdalar Atrophy Scale to Identify Patients With Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Memory Clinic
Patients identified as LATE by the integration of AAS with AD biomarkers had generally mild amnestic cognitive impairment, significant limbic atrophy, and slow decline over time, all features consistent with previous autopsy series. Moreover, AD/LATE cases were more impaired than those with LATE or AD alone. Prospective and neuropathologic validation is warranted.
Authors
- Francesca B. Pizzini (ORCID: https://orcid.org/0000-0002-6285-0989)
- Augusto J. Mendes (ORCID: https://orcid.org/0000-0002-9497-0707)
- Fausto Roveta (ORCID: https://orcid.org/0000-0001-7230-7819)
- Valentina Garibotto (ORCID: https://orcid.org/0000-0003-2422-698X)
- Aurélien Lathuilière (ORCID: https://orcid.org/0000-0002-5191-5214)
- Federica Ribaldi (ORCID: https://orcid.org/0000-0001-9208-4472)
- Innocenzo Rainero (ORCID: https://orcid.org/0000-0001-6074-9628)
- Christian Chicherio (ORCID: https://orcid.org/0009-0004-9845-2618)
- Valerio Natale
- Chen Wang
- Giovanni B. Frisoni
- Max Scheffler
Institutions
- University of Geneva (CH)
- University of Verona (IT)
- University Hospital of Geneva (CH)
- Neuroscience Institute (IT)
- Centre d'Imagerie BioMedicale (CH)
- Geneva College (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1212/wnl.0000000000214477
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00