Phased Variant–Supported Circulating Tumor DNA as a Prognostic Biomarker After First-Line Treatment in Large B-Cell Lymphoma: Findings From the DIRECT Study
EoT PV-MRD enables sensitive and clinically meaningful response assessment in LBCL. It provides independent prognostic information, enhancing EoT response assessment beyond conventional radiologic assessment. Our findings support the incorporation of PV-MRD into clinical trials and routine management of diffuse LBCL.
Authors
- Duane C. Hassane (ORCID: https://orcid.org/0000-0002-0719-9572)
- Natasha H. Cutmore
- Steven A. Frost (ORCID: https://orcid.org/0000-0002-8879-0486)
- Alimu Dayimu
- Jane Price
- Aleksandra A. Kolodziejczyk (ORCID: https://orcid.org/0000-0002-2903-8884)
- Livia Raso-Barnett
- R Goodhew
- Ramona-Rita Barbara
- Christopher S. Trethewey (ORCID: https://orcid.org/0000-0001-9128-3533)
- Furqaan Ahmed Kaji (ORCID: https://orcid.org/0000-0002-1649-563X)
- Philip Barry
- Ilias Moutsopoulos (ORCID: https://orcid.org/0000-0003-4584-7849)
- Veerendra Munugalavadla (ORCID: https://orcid.org/0000-0002-2390-3822)
- Sateesh Nagumantry (ORCID: https://orcid.org/0000-0002-4204-5317)
- Daniel J. Hodson (ORCID: https://orcid.org/0000-0001-6225-2033)
- Julie Smith (ORCID: https://orcid.org/0000-0003-1135-1191)
- Silvia Tarantino (ORCID: https://orcid.org/0000-0003-3283-482X)
- Mamatha Karanth
- Nikhil Shah (ORCID: https://orcid.org/0000-0002-4349-4309)
- Christopher P. Fox (ORCID: https://orcid.org/0000-0002-6322-9254)
- Martin G. Thomas (ORCID: https://orcid.org/0000-0003-2469-824X)
- Joanna A. Krupka (ORCID: https://orcid.org/0000-0003-0369-0329)
- Kay Elston
- Anver Kamil
- Heok Cheow (ORCID: https://orcid.org/0009-0001-4860-8766)
- Lee Elzubeir
- Fabiana Mariscotti
- Nikolaos Demiris
- Shubha Anand
- Matthew Ahearne
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- University of Leicester (GB)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Peterborough City Hospital (GB)
- Norfolk and Norwich University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Cambridge Center (GB)
- United Learning (GB)
- AstraZeneca (Australia) (AU)
- West Suffolk Hospital (GB)
- AstraZeneca (Poland) (PL)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- Athens University of Economics and Business (GR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1200/jco-25-01587
- Citations
- 3
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.41