Inhibitory Effect of Fucoidan Combined with <i>Bifidobacteria</i> on <i>Helicobacter pylori</i>

In the study, fucoidan (FUC) was shown to have antigastric digestive properties and promote the growth of <i>B. animalis</i> BD7, a gastric fluid-resistant, highly aggregative <i>Bifidobacterium</i>. The combination of FUC and <i>B. animalis</i> BD7 significantly inhibited the adhesion of <i>H. pylori</i> SS1 to gastric mucosal epithelial cells (GES-1), decreased urease activity (71.24 ± 3.29%), and promoted the synthesis of bacterial inhibitory substances <i>in vitro</i>, while <i>in vivo</i>, it could alleviate the inflammation of the gastric mucosa of the infected mice, regulate the level of inflammatory factors, and repair the mucosal barrier by a mechanism that is related to the inhibition of the TLR2/MyD88/NF-κB pathway and reversal of bacterial colony disorders. The mechanism is related to the inhibition of the TLR2/MyD88/NF-κB pathway and the reversal of flora disruption. The synergistic effects of the two provide theoretical and practical basis for the development of new anti-<i>H. pylori</i> food and optimization of clinical treatment.