TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice
This study furthers understanding of the therapeutic potential of TRPC4/TRPC5 channel inhibition for excessive aversion processing and impaired reward processing.
Authors
- B. Hengerer
- Sophie Simard (ORCID: https://orcid.org/0009-0001-1776-802X)
- Naguib Mechawar
- Christopher Pryce
- Hannes Sigrist
- M. Robert
- Stefan Just
- A Senn
- Lorraine Madur
- Deniz Queisser
- Giulia Poggi
- Nagiua Cuomo‐Haymour
- Sophie Schmid
- Adrián Portalés
- Diana Kúkeľová
Institutions
- Boehringer Ingelheim (Germany) (DE)
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- McGill University (CA)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/bph.70305
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00