Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort
In a national cohort of newly decompensated cirrhosis Veterans, SBP increased mortality, which worsened with recurrence. SBP prophylaxis (primary or secondary) showed an interaction with higher mortality but not LT. Antibiotic resistance increased with SBPPr, but culture results were not followed while resuming/initiating SBPPr. Novel strategies to prevent SBP recurrence and mortality are needed.
Authors
- Jacqueline O'leary
- Simona Jakab (ORCID: https://orcid.org/0000-0002-0695-0758)
- Scott Silvey (ORCID: https://orcid.org/0000-0003-4540-4239)
- Jasmohan Singh Bajaj (ORCID: https://orcid.org/0000-0003-4928-3681)
- Timothy R. Morgan (ORCID: https://orcid.org/0000-0003-1328-0307)
- J. Daniel Markley (ORCID: https://orcid.org/0009-0002-7644-9720)
- Heather Patton (ORCID: https://orcid.org/0000-0003-3581-5237)
- Shari Rogal
- Nilang Patel
Institutions
- Virginia Commonwealth University (US)
- VA Connecticut Research and Education Foundation (US)
- Long Beach Medical Center (US)
- University of California San Diego Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Dallas VA Medical Center (US)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/apt.70498
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- U.S. Department of Veterans Affairs
- National Center for Advancing Translational Sciences