Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes
Our findings suggest that the observed behavioural changes are associated with dysfunction of the noradrenergic α<sub>2</sub>-adrenoceptor system induced by impaired glucose metabolism. These insights targeting the noradrenergic-metabolic axis might be a new strategy for sugar-induced depression subtypes.
Authors
- Tomoya Sugai
- Noriki Kutsumura (ORCID: https://orcid.org/0000-0002-1494-2133)
- Akihiro Mouri
- Kuniaki Saito
- Hidetoshi Matunami
- Hitomi Kurahashi
- Yumiko Seto
- Toshitaka Nabeshima
- Masaya Hasegawa
- Masao Takemura
- Aoi Ogawa
- Yasuko Yamamoto
- Kazuo Kunisawa
- Takatoshi Sakata
Institutions
- Fujita Health University (JP)
- University of Tsukuba (JP)
- Matsunami General Hospital (JP)
- Hokkaido Research Organization (JP)
- Tsukuba International University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/bph.70288
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- Smoking Research Foundation
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency