Exosome profile and composite indices reflect immune exhaustion in periodontitis
Composite exosomal indices reflect the balance between canonical biogenesis, immune cell-derived vesicles, and cell damage-associated vesicles in periodontitis. The negative association of CD81 and Immune Index with disease severity suggests immune exhaustion, whereas reduced IL-10 supports impaired regulatory control in advanced stages.
Authors
- Francisco Mesa (ORCID: https://orcid.org/0000-0001-8943-9068)
- Irene Peñalver
- Manuel Bravo
- Marco Bonilla
Institutions
- Universidad de Granada (ES)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1038/s41598-025-32970-3
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Junta de Andalucía