Preliminary Results on the Added Value of Parametric Images Derived from 18F-fluoroethyl-L-tryptophan PET for Posttreatment Glioblastoma Assessment
Areas of high tryptophan metabolism detected by [<sup>18</sup>F]FETrp PET-derived parametric (K<sub>i</sub>) maps extend outside the contrast-enhancing glioblastoma mass in adjacent non-enhancing brain regions that can be missed or underestimated by static uptake images. Consequently, [<sup>18</sup>F]FETrp PET metabolic maps have the potential for enhanced detection of non-enhancing glioma infiltration for improved radiation or surgical treatment planning.
Authors
- M.M. Dominello
- Geoffrey Barger
- Csaba Juhász (ORCID: https://orcid.org/0000-0002-5067-5554)
- Parthasarathi Chamiraju
- Natasha Robinette (ORCID: https://orcid.org/0000-0001-7859-0037)
- Otto Muzik
- Huailei Jiang
Institutions
- Wayne State University (US)
- Detroit Medical Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1007/s11307-025-02075-4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00