Network Pharmacology and Experimental Validation Reveal Aidi Injection Suppresses Prostate Cancer via EGFR Inhibition and STAT3-Mediated Apoptosis
Aidi injection influences the IL-6/STAT3 and EGFR pathways, suppressing PCa cell growth, inducing apoptosis, and reducing migration and invasion. These findings offer valuable insights into the therapeutic potential of Aidi injection for prostate cancer.
Authors
- Yuehai Xiao (ORCID: https://orcid.org/0000-0001-6877-9952)
- Ganhua You (ORCID: https://orcid.org/0000-0001-5994-5840)
- X. Chen
- Chen Qian
- Jukun Song
- Qunying An
Institutions
- Guiyang Medical University (CN)
- Hengshui University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Biological Procedures Online
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12575-025-00299-w
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou University of Chinese Medicine
- Guangzhou University