Hyperbilirubinemia and phototherapy differentially alter hippocampal transcriptome in the preterm Gunn rat model
This study utilized a model of phototherapy treatment in a preterm Gunn rat model of hyperbilirubinemia. Data demonstrate that mild hyperbilirubinemia, and to an even greater extent, phototherapy, induces widespread gene expression changes in the developing hippocampus. Phototherapy was associated with differentially expressed genes related to neurogenesis, synaptogenesis, and microtubule dynamics.
Authors
- Eric F. Lock (ORCID: https://orcid.org/0000-0003-4663-2356)
- Raghavendra Rao (ORCID: https://orcid.org/0000-0002-6089-5972)
- Katherine M. Satrom (ORCID: https://orcid.org/0000-0003-0893-3641)
- Troy C. Lund
- Phu V. Tran
Institutions
- University of Minnesota (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1038/s41390-025-04700-y
- Citations
- 1
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- University of Minnesota
- National Institutes of Health