Cholesterol-mediated inflammation activation in alveolar macrophages
In alveolar macrophages, cholesterol crystals, but not soluble cholesterol, trigger the assembly and activation of the inflammasome, thus leading to the inflammasome-dependent release of IL-18. These results open new scenarios for the role of alveolar macrophages and of cholesterol-mediated inflammation in the lung.
Authors
- Sonia Giambelluca (ORCID: https://orcid.org/0000-0001-7425-7958)
- Elena López-Rodríguez (ORCID: https://orcid.org/0000-0002-1549-8150)
- Matthias Ochs (ORCID: https://orcid.org/0000-0002-0936-6979)
Institutions
- German Center for Lung Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12915-025-02494-3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00