YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation
TCF4 targeted the promoter region of m6A reader YTHDF1 to promote its transcription, thereby reducing osteoblast ferroptosis in TN-induced periprosthetic osteolysis by promoting the translation of GPX4 and SLC7A11.
Authors
- Lemei Zhu (ORCID: https://orcid.org/0000-0003-0477-3759)
- Da Zhong (ORCID: https://orcid.org/0009-0001-9632-4012)
- Kunli Chen
- Fawei Gao
- Hua Liu (ORCID: https://orcid.org/0000-0003-2985-1821)
- J M Tian
- Ke Yin
- Zhan Liao
- Xi Li
- Long Wang
- Chenggong Wang
- Wenqing Xie
- Zhen Yin
- Ganzhe Xu
- Peng Chen
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- First Affiliated Hospital of University of South China (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12951-025-03861-6
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Central South University
- Division of Graduate Education