Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models

These findings highlight the αSyn-ClpP interaction as a druggable target and support CS2 as a potential disease-modifying therapy for PD and related synucleinopathies.

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Publication Details

Journal
Molecular Neurodegeneration
Published
2025-12-22
DOI
https://doi.org/10.1186/s13024-025-00918-w
Citations
1
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
1.39

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article

Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models

Xiaoyan Sun, Xin Qi, Di Hu
1 citations
Molecular Neurodegeneration
Parkinson's Disease Mechanisms and Treatments
1.39
article

Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models

Xiaoyan Sun, Xin Qi, Di Hu
article en
1 citations

Abstract

These findings highlight the αSyn-ClpP interaction as a druggable target and support CS2 as a potential disease-modifying therapy for PD and related synucleinopathies.

Molecular NeurodegenerationVol. 20(1)
University School (US), Case Western Reserve University (US)
University of Toronto, National Institutes of Health
Openalex Percentile: Top 13%
Parkinson's Disease Mechanisms and Treatments
1.39
DOIOpen Access PDFOpenAlex
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