Postoperative absence of residual intracranial tumor volume is associated with improved survival and intracranial disease control in non-small cell lung cancer brain metastases
Achieving complete intracranial tumor resection, rather than the amount of postoperative residual volume, was consistently associated with improved survival and intracranial disease control. These findings support the clinical relevance of GTR in selected NSCLC-BM patients and may inform patient counselling and surgical decision-making, while warranting further investigation in patients with multifocal but safely resectable intracranial disease.
Authors
- Meltem Gönel (ORCID: https://orcid.org/0000-0002-8652-0554)
- Victor E. Staartjes (ORCID: https://orcid.org/0000-0003-1039-2098)
- Anna Maria Zeitlberger (ORCID: https://orcid.org/0000-0002-9837-5534)
- Flavio Vasella (ORCID: https://orcid.org/0000-0002-8953-0862)
- J. Fierstra
- Jacopo Bellomo (ORCID: https://orcid.org/0009-0005-8945-4838)
- Marian Christoph Neidert (ORCID: https://orcid.org/0000-0003-2828-4706)
- Stefanos Voglis (ORCID: https://orcid.org/0000-0002-1514-1442)
- Carlo Serra (ORCID: https://orcid.org/0000-0002-7305-550X)
- Luis Padevit (ORCID: https://orcid.org/0000-0003-2461-0404)
- Luca Regli (ORCID: https://orcid.org/0000-0003-4639-4474)
- Nicolin Hainc (ORCID: https://orcid.org/0000-0003-0916-7387)
- Émilie Le Rhun (ORCID: https://orcid.org/0000-0002-9408-3278)
- Vittorio Stumpo (ORCID: https://orcid.org/0000-0002-8175-0035)
- Tristan Schmidlechner (ORCID: https://orcid.org/0009-0006-0915-5983)
- Isabelle Opitz
- Maria Nikolaeva
- Michael Weller
- Oliver Bozinov
- Jonathan Sutter
Institutions
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- OST - Ostschweizer Fachhochschule (CH)
- Ostschweizer Kinderspital (CH)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1007/s11060-025-05387-1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00