Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging
Together, these findings provide in vivo evidence for early, cortical layer-specific neurovascular dysfunction caused by APOE4 that increases the susceptibility to dementia and highlight the potential of combining neurovascular biomarkers from optical imaging with AI-based classifier for identification of increased AD/ADRD risk.
Authors
- Nora D. Volkow (ORCID: https://orcid.org/0000-0001-6668-0908)
- Jiaxiang Ren
- Hyomin Jeong (ORCID: https://orcid.org/0009-0005-9970-7069)
- Wensheng Cheng
- Congwu Du
- Yingtian Pan
- Haibin Ling
- Donghui Zhu
Institutions
- National Institutes of Health (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Stony Brook University (US)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s40035-025-00530-4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00