Immunomodulatory effect of ultrasound-guided cryoablation in early breast cancer: pilot study on blood and surgical samples
Cryoablation is a promising nonsurgical treatment for early-stage BC. The procedure may induce immune activation by increasing HMGB1 and modulating T-cell populations. Tregs appear to decrease after cryoablation, suggesting immunomodulatory potential. Histopathology confirms effective tumor ablation in most treated patients. Cryoablation shows immunomodulatory effects and may provide a rationale for future combination with immunotherapy.
Authors
- Chiara Napoletano (ORCID: https://orcid.org/0000-0001-5449-5430)
- Bruna Cerbelli (ORCID: https://orcid.org/0000-0001-5419-2309)
- Federica Pediconi
- Andrea Botticelli
- Veronica Rizzo (ORCID: https://orcid.org/0000-0003-1781-3174)
- Giulia d’Amati (ORCID: https://orcid.org/0000-0002-6959-691X)
- Angelica Pace (ORCID: https://orcid.org/0000-0003-2097-7874)
- Aurelia Rughetti (ORCID: https://orcid.org/0000-0002-1863-8251)
- Lucrezia Tuosto
- Marianna Nuti
- Francesca Galati
Institutions
- Sapienza University of Rome (IT)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s41747-025-00655-1
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sapienza Università di Roma