Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
PS-MPs promote NPC progression by generating mitochondrial ROS that activate the NRF2-SLC7A11/GPX4 antioxidant axis and suppress ferroptosis. Pharmacologic reactivation of ferroptosis counteracts these effects, highlighting ferroptosis-targeted therapy as a potential strategy for mitigating microplastic-associated cancer risk.
Authors
- Xiangying Deng
- Lin Zhao
- Xinglong Liu
- Juan Feng
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12967-025-07508-w
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00