Antibiotic De-Escalation in Adults Hospitalized for Community-Onset Sepsis
In this study, de-escalation of empiric BSA therapy at day 4 was associated with similar safety outcomes, fewer antibiotic days, and shorter length of hospitalization among patients with community-onset sepsis compared with those who continued BSA therapy but varied widely in practice.
Authors
- Tejal Gandhi (ORCID: https://orcid.org/0000-0002-0958-6445)
- Lindsay A Petty (ORCID: https://orcid.org/0000-0002-8731-105X)
- Stephanie Parks Taylor (ORCID: https://orcid.org/0000-0001-6163-9666)
- David Ratz
- Tawny Czilok
- Elizabeth S. Munroe (ORCID: https://orcid.org/0000-0003-3353-612X)
- A K Gupta
- Emily Walzl (ORCID: https://orcid.org/0009-0007-1760-976X)
- Elizabeth McLaughlin
- Scott A. Flanders
- Valerie M. Vaughn
- Megan Heath
- Hallie C. Prescott
- Anurag N. Malani
- Lama Hsaiky
- Patricia Posa
- Jennifer K. Horowitz
Institutions
- Trinity Health (US)
- University of Utah (US)
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- VA Center for Clinical Management Research (US)
- Utah Department of Health (US)
- Beaumont Hospital, Dearborn (US)
Publication Details
- Journal
- JAMA Internal Medicine
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1001/jamainternmed.2025.6919
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- U.S. Department of Veterans Affairs
- Agency for Healthcare Research and Quality