Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity
Our results demonstrate that Schwann cell LRP1 safeguards mitochondrial function and supports neuron-glia metabolic coupling in the trigeminal system. The finding that LRP1 deficiency in Schwann cells drives orofacial pain in the absence of external insults highlights Schwann cells as active drivers, rather than passive amplifiers of chronic pain and identifies LRP1 as a promising target for orofacial pain management.
Authors
- Bradley E. Aouizerat (ORCID: https://orcid.org/0000-0002-6047-9397)
- Stefano Martellucci (ORCID: https://orcid.org/0000-0002-3952-3162)
- Kesava Asam (ORCID: https://orcid.org/0000-0002-6247-9905)
- Naijiang Liu
- W. Marie Campana (ORCID: https://orcid.org/0000-0002-9039-1396)
- Yi Ye
- zhiting gong
- Morgan Zhang
Institutions
- University of San Diego (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- New York University (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s10194-025-02250-6
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16