Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

In vitro potency of synthetic cannabinoid receptor agonists (SCRAs) does not clearly correlate with harm potential, and hence other properties of the SCRAs seem to be involved. The risk score introduced here provides a novel framework for assessing the potential hazards of emerging SCRAs by integrating routine forensic data with clinical intoxication case analyses.

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Publication Details

Journal
Addiction
Published
2025-12-21
DOI
https://doi.org/10.1111/add.70268
Primary Topic
Forensic Toxicology and Drug Analysis
Type
article
Field-Weighted Citation Impact
0.00

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article

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Volker Auwärter, Katharina Elisabeth Grafinger, Michaela J. Sommer, Maren Hermanns‐Clausen
Addiction
Forensic Toxicology and Drug Analysis
article

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Volker Auwärter, Katharina Elisabeth Grafinger, Michaela J. Sommer, Maren Hermanns‐Clausen
article en

Abstract

In vitro potency of synthetic cannabinoid receptor agonists (SCRAs) does not clearly correlate with harm potential, and hence other properties of the SCRAs seem to be involved. The risk score introduced here provides a novel framework for assessing the potential hazards of emerging SCRAs by integrating routine forensic data with clinical intoxication case analyses.

AddictionVol. 121(4)
University of Bern (CH), University of Freiburg (DE), University Medical Center Freiburg (DE)
National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Albert-Ludwigs-Universität Freiburg, Universiteit Gent
Good health and well-being
Openalex Percentile: Top 35%
Forensic Toxicology and Drug Analysis
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Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data — Volker Auwärter, Katharina Elisabeth Grafinger, et al. · Addiction (2025) | TGRS Research Map | TGRS