Effectiveness of platelet-rich plasma plus microfracture compared with microfracture alone in the treatment of knee cartilage lesions: a systematic review and meta-analysis of comparative studies

Compared with MF alone, PRP + MF produced clinically meaningful improvement in functional outcomes and pain control. The results of the present study may provide preliminary evidence for selecting treatments for knee cartilage lesions. However, higher-quality clinical studies with more quantitative outcomes are needed to confirm these results and determine the long-term effectiveness and safety of PRP augmentation following MF.