Does hypoxemia aggravate sepsis-associated acute kidney injury? Integrated clinical and experimental evidence
These clinical and experimental findings indicate that hypoxemia was not independently associated with aggravated renal injury in SA-AKI and may activate HIF-1α and promote adaptive mitophagy. This challenges the conventionally held belief that hypoxemia is uniformly detrimental to renal function during sepsis.
Authors
- J Li
- Jiayue Xu (ORCID: https://orcid.org/0000-0002-6633-6522)
- Haoyun Mao (ORCID: https://orcid.org/0009-0006-6794-3523)
- Y. Zhu
- Xiaodong Zhu (ORCID: https://orcid.org/0000-0002-7989-6326)
- Yaya Xu
- Xiangmei Kong
Institutions
- XinHua Hospital (CN)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1186/s40635-025-00840-x
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University