Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment

Higher CAIDE dementia risk scores were linked to poorer cognitive performance but showed limited association with WMH burden in individuals with MCI. Gray matter and hippocampal volumes were stronger correlates of dementia risk than WMH volume and CAIDE-related risk may be better captured by cortical and hippocampal structural changes rather than white matter disease.

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Publication Details

Journal
IBRO Neuroscience Reports
Published
2025-12-21
DOI
https://doi.org/10.1016/j.ibneur.2025.12.007
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment

Yasaman Abtahi, Mahsa Mayeli, Fatemeh Gila, Farshad Goharmanesh et al.
IBRO Neuroscience Reports
Dementia and Cognitive Impairment Research
article

Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment

Yasaman Abtahi, Mahsa Mayeli, Fatemeh Gila, Farshad Goharmanesh, Zahra Gharehdaghi, Hamide Nasiri, Marjan Falahati, Laya Dalir, Parham Mahmoudi, Mohammad Hossein Nourbakhshi, Raziyeh Zamiri, Yousef Nourbakhsh, Saeed Omidi, Marziye Jalalian Chaleshtari, Hannaneh Azimizonuzi, Sheyda Sharabiani
article en

Abstract

Higher CAIDE dementia risk scores were linked to poorer cognitive performance but showed limited association with WMH burden in individuals with MCI. Gray matter and hippocampal volumes were stronger correlates of dementia risk than WMH volume and CAIDE-related risk may be better captured by cortical and hippocampal structural changes rather than white matter disease.

IBRO Neuroscience ReportsVol. 20
Zanjan University of Medical Sciences (IR), Sharif University of Technology (IR), Shiraz University of Medical Sciences (IR), Allameh Tabataba'i University (IR), Islamic Azad University, Karaj (IR), University of Tehran (IR), Islamic Azad University Medical Branch of Tehran (IR), Zabol University of Medical Sciences (IR), Kermanshah University of Medical Sciences (IR), Islamic Azad University Rasht Branch (IR), Iranian Orthopedic Association (IR), University of Social Welfare and Rehabilitation Sciences (IR), Tehran University of Medical Sciences (IR)
U.S. Department of Defense, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, Meso Scale Diagnostics, BioClinica, Novartis Pharmaceuticals Corporation, Northern California Institute for Research and Education, Eisai, Servier, H. Lundbeck A/S, IXICO, National Institutes of Health, Genentech, Canadian Institutes of Health Research
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Dementia and Cognitive Impairment Research
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