Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD
Chronic intestinal inflammation reshapes the epithelial stem and progenitor cell compartment, promoting altered differentiation and the emergence of immune-responsive epithelial states. These findings highlight the plasticity of the human intestinal epithelium in IBD and point to new avenues for therapeutic strategies aimed at maintaining epithelial integrity during chronic inflammation.
Authors
- Shivam Patel (ORCID: https://orcid.org/0009-0000-0178-2073)
- G W Moran
- Louis Gall (ORCID: https://orcid.org/0000-0002-1805-2357)
- William Dalleywater (ORCID: https://orcid.org/0000-0002-4735-2105)
- Brinda Balasubramanian (ORCID: https://orcid.org/0000-0003-4808-9748)
- Joerg Huelsken (ORCID: https://orcid.org/0000-0003-3105-9606)
- Carmen Margarita Miranda Pin
- Paloma Ordóñez-Morán
- Nick Hannan
Institutions
- University of Nottingham (GB)
- AstraZeneca (South Korea) (KR)
- AstraZeneca (Poland) (PL)
- Nottingham Biomedical Research Centre (GB)
- Swiss Cancer Center Léman (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Birmingham (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1186/s13287-025-04872-8
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00