Modulating the immune response in Swiss albino mice using Arabic gum (Acacia)

Arabic Gum is a soluble dietary fiber with important biological properties and is effectively used to improve the immune system. It promotes the growth of beneficial bacteria in the gut (probiotics), is considered a digestive enhancer, and is also known to help strengthen the immune system. Some research has indicated its anti-inflammatory and immunomodulatory properties. This study investigated the effects of Arabic gum extract on the immune response and weight variation in Swiss albino mice. The Swiss albino rats were divided into five groups as follows: the group one was considered control (T0, untreated), the group two (T1) was given 30 mg/kg arabic gum + ovalbumin (0.1 ml), the group three (T2) was given 60 mg/kg arabic gum + ovalbumin (0.1 ml), the fourth group (T3) was given 90 mg/kg arabic gum + ovalbumin (0.1 ml), and finally the fifth group (T4, standard) was given ovalbumin (0.1 ml) alone. The maximum concentration (90mg/kg) led to consistent gain of weight implying a potential positive immunomodulatory effect or metabolic increase. Arabic gum extract showed potent neutrophil count in a dose dependent fashion, implying that Arabic gum extract caused an improved innate immune response, Arabic gum extract portrayed potent immunomodulatory effect, whereby it reduced oedema volume dose dependently, indicating anti-inflammatory effects . This study suggests that Arabic gum extract has the potential to modulate the immune response and exert anti-inflammatory effects in Swiss albino mice. Further research is needed to explore the mechanisms of action and potential clinical applications.