Intermittent Resistance Training and Algomed Algae Supplementation Reduce ANGPTL3 and ANGPTL4 in Obese Men: A 12-Week Intervention Study

Background: This study aimed to investigate the effects of a 12-week intermittent resistance training program combined with Algomed algae supplementation on serum levels of angiopoietin-like proteins 3 and 4 (ANGPTL3 and ANGPTL4) in overweight men. Methods: In this semi-experimental study, 44 overweight men aged 23–32 years were randomly assigned to one of four groups: resistance training (n = 11), supplementation (n = 11), training + supplementation (n = 11), and control (n = 11). The resistance training protocol consisted of 8 upper and lower body exercises performed intermittently in 3 sets of 13 repetitions at 60% of one-repetition maximum (1RM), with active rest between sets at 20% 1RM for 15 repetitions. The supplement groups consumed 1800 mg of Algomed algae daily (six tablets), following the manufacturer's instructions. Serum levels of ANGPTL3 and ANGPTL4 were measured via ELISA. Statistical analysis included paired t-tests, ANCOVA, and Tukey's post hoc test, with significance set at p < 0.05. Results: ANCOVA revealed significant differences in ANGPTL3 and ANGPTL4 changes between control and intervention groups (p < 0.001). The combined group showed significantly greater reductions than the training group (p = 0.026) and the supplement group (p < 0.001). Tukey’s post hoc test confirmed these differences (training: p = 0.049; supplementation: p = 0.03). Conclusion: Intermittent resistance training combined with Algomed supplementation significantly reduces serum ANGPTL3 and ANGPTL4 levels, potentially through modulation of LPL activity. These effects may contribute to improved inflammatory profiles and reduced adiposity in overweight individuals.