Synthesis of 5-Cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-sulfanylidene-1,6-dihydropyridine-3-carboxamide Derivatives
Multicomponent reaction of 4-nitrobenzaldehyde, cyanothioacetamide, N-(2-methylphenyl)-3-oxobutanamide, and alkyl halides in boiling ethanol in the presence of 2 equiv of potassium hydroxide afforded 5-cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-sulfanylidene-1,6-dihydropyridine-3-carboxamide derivatives such as 2-(alkylsulfanyl)pyridines and 3-aminothieno[2,3-b]pyridines in 64–91% yields.
Authors
- S. G. Krivokolysko
- B. S. Krivokolysko
- D. V. Nikitenko
Institutions
- Luhansk State Medical University (UA)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1134/s1070428025603036
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00