Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old
Our findings highlight that, as far as we aware, previously unrecognized oral microbiome composition links to lower mAge deviation and better cognitive function among the oldest-old, suggesting a potential role of the oral microbiome in promoting healthy aging and informing future mechanistic investigations.
Authors
- W. Wang (ORCID: https://orcid.org/0000-0002-8469-8797)
- Brian Keith Kennedy (ORCID: https://orcid.org/0000-0002-5754-1874)
- Andrea Britta Maier (ORCID: https://orcid.org/0000-0001-7206-1724)
- CL Ho
- Feng Lin (ORCID: https://orcid.org/0000-0002-5996-8812)
- Lihuan Guan (ORCID: https://orcid.org/0000-0003-0497-8519)
- Tze Pin Ng
- Yap Seng Chong
- Jian Hua Tay (ORCID: https://orcid.org/0009-0004-4399-7215)
- Ashok Venkitaraman
- Tim Wehnes
- Woon-Puay Koh
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Singapore Institute of Technology (SG)
- Singapore Institute for Clinical Sciences (SG)
- National University Cancer Institute, Singapore (SG)
- National Cancer Centre Singapore (SG)
- National University Health System (SG)
- Institute of Molecular and Cell Biology (SG)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1038/s43856-025-01288-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Agency for Science, Technology and Research
- National University Health System
- Medical Research Council
- National Medical Research Council