Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8 <sup>+</sup> T Cell Function in the Context of Treatment- Free Remission

This study evaluated the immune surveillance function in chronic myeloid leukemia (CML) through tumor antigen gene expression analysis, <i>in vitro</i> mixed lymphocyte cultures with peptides, and immunological analysis of patients after imatinib withdrawal to investigate factors affecting treatment-free remission (TFR). Specific immune responses were demonstrated in T lymphocytes against SPAG9 and NY-REN-60 peptides, highlighting their potential in immunotherapy. Immune profiling identified that CD8<sup>+</sup>PD1<sup>+</sup>, CD56<sup>dim</sup>CD16<sup>+</sup>PD1<sup>+</sup>, and iNKT<sup>+</sup>CD161<sup>+</sup> cells contribute to recurrence-free survival. A Cox model confirmed the prognostic value of immune markers. These results emphasize the critical role of the immune system in CML and indicate novel targets for sustaining TFR.

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Publication Details

Journal
Archivum Immunologiae et Therapiae Experimentalis
Published
2025-12-20
DOI
https://doi.org/10.2478/aite-2026-0004
Primary Topic
Chronic Myeloid Leukemia Treatments
Type
article
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article

Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8 + T Cell Function in the Context of Treatment- Free Remission

T. Sacha, Michał Kiełbus, Agnieszka Karczmarczyk, K. Giannopoulos et al.
Archivum Immunologiae et Therapiae Experimentalis
Chronic Myeloid Leukemia Treatments
article

Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8 + T Cell Function in the Context of Treatment- Free Remission

T. Sacha, Michał Kiełbus, Agnieszka Karczmarczyk, K. Giannopoulos, Magdalena Paziewska, Joanna Zaleska, Paulina Kwaśnik, Magdalena Zawada, Katarzyna Skórka, Michalina Pinkosz, Dorota Link-Lenczowska, Paweł Cech, Martyna Stępień
article en

Abstract

This study evaluated the immune surveillance function in chronic myeloid leukemia (CML) through tumor antigen gene expression analysis, <i>in vitro</i> mixed lymphocyte cultures with peptides, and immunological analysis of patients after imatinib withdrawal to investigate factors affecting treatment-free remission (TFR). Specific immune responses were demonstrated in T lymphocytes against SPAG9 and NY-REN-60 peptides, highlighting their potential in immunotherapy. Immune profiling identified that CD8<sup>+</sup>PD1<sup>+</sup>, CD56<sup>dim</sup>CD16<sup>+</sup>PD1<sup>+</sup>, and iNKT<sup>+</sup>CD161<sup>+</sup> cells contribute to recurrence-free survival. A Cox model confirmed the prognostic value of immune markers. These results emphasize the critical role of the immune system in CML and indicate novel targets for sustaining TFR.

Archivum Immunologiae et Therapiae ExperimentalisVol. 74(1)
Medical University of Lublin (PL), Jagiellonian University (PL), University of Agriculture in Krakow (PL), Krakow Cardiovascular Research Institute (PL)
Good health and well-being
Openalex Percentile: Top 26%
Chronic Myeloid Leukemia Treatments
DOIOpen Access PDFOpenAlex
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Immune Surveillance in Chronic Myeloid Leukemia: Tumor Antigen Expression and CD8 <sup>+</sup> T Cell Function in the Context of Treatment- Free Remission — T. Sacha, Michał Kiełbus, et al. · Archivum Immunologiae et Therapiae Experimentalis (2025) | TGRS Research Map | TGRS