Amyloid and tau pathologies are drivers of white matter damage in aging and Alzheimer’s disease
These findings suggest that Aβ and tau pathology drive future WMH progression rather than the reverse, with distinct regional patterns for each pathology type.
Authors
- Farooq Kamal (ORCID: https://orcid.org/0000-0001-5197-3062)
- Mahsa Dadar (ORCID: https://orcid.org/0000-0003-4008-2672)
Institutions
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-19
- DOI
- https://doi.org/10.64898/2025.12.18.25342588
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Biogen
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Réseau en Bio-Imagerie du Quebec
- Alzheimer Society
- Eisai
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Alzheimer Society Research Program
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé