C-reactive protein in adult sepsis: systematic review and meta-analysis
Current evidence reveals high diagnostic uncertainty and limited prognostic accuracy of CRP in adults with sepsis. The low specificity and high error rates restrict the clinical utility of CRP for diagnostic or prognostic decision-making in sepsis management.
Authors
- Clara Lucato dos Santos (ORCID: https://orcid.org/0000-0002-7381-9426)
- Luca Schiliró Tristão (ORCID: https://orcid.org/0000-0002-7197-0915)
- Wanderley Marques Bernardo
- Luís Eduardo Miranda Paciência
- Antonio Silvinato
- Eliane Amorim
- Idevaldo Floriano
Institutions
- Brazilian Medical Association (BR)
- Irmandade da Santa Casa de Misericórdia de São Paulo (BR)
- Evidence Based Research (United States) (US)
- Governo do Estado de São Paulo (BR)
- Faculdade de Medicina do ABC (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital São Paulo (BR)
Publication Details
- Journal
- Clinics
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1016/j.clinsp.2025.100848
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35