First molecular insight into Ovar-DRB1 exon 2 in Edilbay sheep: High heterozygosity and detection of novel variants

This study presents the first comprehensive molecular characterization of <i>Ovar-DRB1</i> exon 2 in Edilbay sheep, revealing exceptionally high genetic diversity and strong evidence for previously undescribed alleles. These findings broaden the catalog of DRB1 variants and highlight the breed's adaptive immunogenetic potential. Further investigations using allele-specific amplification, cloning, or next-generation sequencing are recommended to precisely identify novel variants and explore associations with disease resistance and environmental adaptation.