Solitary Fibrous Tumor of Uterine Cervix: A Rare Entity Mimicking Clinically as Carcinoma Cervix

Solitary fibrous tumors (SFTs) are a rare spindle cell neoplasm arising from mesenchymal cells. It was first described in the pleura. There are numerous reports that document their extrapleural locations. SFT involving the cervix is extremely rare and only a handful of cases have been reported in Indian and western literature. Previously, it was thought that SFT tumor cells differentiated from mesothelial cells into fibroblasts. With the advent of immunohistochemistry, it is revealed that tumor cells in SFT lack mesothelial characteristics but express CD34 and Bcl-2, suggesting that the tumor originates from mesenchymal tissue. Preoperative definitive diagnosis of SFT cervix is difficult.

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Publication Details

Journal
International Journal of Applied and Basic Medical Research
Published
2025-10-01
DOI
https://doi.org/10.4103/ijabmr.ijabmr_160_25
Primary Topic
Soft tissue tumor case studies
Type
article
Field-Weighted Citation Impact
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article

Solitary Fibrous Tumor of Uterine Cervix: A Rare Entity Mimicking Clinically as Carcinoma Cervix

Neha Gupta, Shirish Chandanwale, Akshi Raj, Madhuri Singh
International Journal of Applied and Basic Medical Research
Soft tissue tumor case studies
article

Solitary Fibrous Tumor of Uterine Cervix: A Rare Entity Mimicking Clinically as Carcinoma Cervix

Neha Gupta, Shirish Chandanwale, Akshi Raj, Madhuri Singh
article en

Abstract

Solitary fibrous tumors (SFTs) are a rare spindle cell neoplasm arising from mesenchymal cells. It was first described in the pleura. There are numerous reports that document their extrapleural locations. SFT involving the cervix is extremely rare and only a handful of cases have been reported in Indian and western literature. Previously, it was thought that SFT tumor cells differentiated from mesothelial cells into fibroblasts. With the advent of immunohistochemistry, it is revealed that tumor cells in SFT lack mesothelial characteristics but express CD34 and Bcl-2, suggesting that the tumor originates from mesenchymal tissue. Preoperative definitive diagnosis of SFT cervix is difficult.

International Journal of Applied and Basic Medical ResearchVol. 15(4)
Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN)
Good health and well-being
Openalex Percentile: Top 29%
Soft tissue tumor case studies
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