Synthesis of 4-(4-Azidobenzyl)phenol and N-[4-(4-Azidobenzyl)phenyl]acetamide

N-[4-(4-Azidobenzyl)phenyl]acetamide and 4-(4-azidobenzyl)phenol have been synthesized in 57 and 55% yields, respectively, by the diazotization of N-[4-(4-aminobenzyl)phenyl]acetamide and 4-(4-amino­ben­zyl)­phenol with sodium nitrite in excess hydrochloric acid, followed by treatment of the resulting diazonium salts with sodium azide at 0 to –5°C.

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Publication Details

Journal
Russian Journal of Organic Chemistry
Published
2025-10-01
DOI
https://doi.org/10.1134/s1070428025601396
Primary Topic
Chemical Reactions and Mechanisms
Type
article
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article

Synthesis of 4-(4-Azidobenzyl)phenol and N-[4-(4-Azidobenzyl)phenyl]acetamide

A. N. Lobov, R. L. Safiullin, A. N. Teregulova
Russian Journal of Organic Chemistry
Chemical Reactions and Mechanisms
article

Synthesis of 4-(4-Azidobenzyl)phenol and N-[4-(4-Azidobenzyl)phenyl]acetamide

A. N. Lobov, R. L. Safiullin, A. N. Teregulova
article en

Abstract

N-[4-(4-Azidobenzyl)phenyl]acetamide and 4-(4-azidobenzyl)phenol have been synthesized in 57 and 55% yields, respectively, by the diazotization of N-[4-(4-aminobenzyl)phenyl]acetamide and 4-(4-amino­ben­zyl)­phenol with sodium nitrite in excess hydrochloric acid, followed by treatment of the resulting diazonium salts with sodium azide at 0 to –5°C.

Russian Journal of Organic ChemistryVol. 61(10)
Ufa Institute of Chemistry (RU)
Clean water and sanitation
Openalex Percentile: Top 27%
Chemical Reactions and Mechanisms
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Synthesis of 4-(4-Azidobenzyl)phenol and N-[4-(4-Azidobenzyl)phenyl]acetamide — A. N. Lobov, R. L. Safiullin, et al. · Russian Journal of Organic Chemistry (2025) | TGRS Research Map | TGRS