Are sex differences in adolescent depression and anxiety driven by adrenarchal hormones? A causal mediation analysis from a prospective cohort study

Higher DHEA levels were associated with increased risk of depression and anxiety during early adolescence in males. We found no evidence that adrenarchal hormone levels mediated the sex differences in depression and anxiety.

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Publication Details

Journal
Journal of Affective Disorders
Published
2025-12-20
DOI
https://doi.org/10.1016/j.jad.2025.121012
Primary Topic
Hormonal and reproductive studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Are sex differences in adolescent depression and anxiety driven by adrenarchal hormones? A causal mediation analysis from a prospective cohort study

Susan M. Sawyer, Nandita Vijayakumar, S. Ghazaleh Dashti, Dongmei Luo
Journal of Affective Disorders
Hormonal and reproductive studies
article

Are sex differences in adolescent depression and anxiety driven by adrenarchal hormones? A causal mediation analysis from a prospective cohort study

Susan M. Sawyer, Nandita Vijayakumar, S. Ghazaleh Dashti, Dongmei Luo
article en

Abstract

Higher DHEA levels were associated with increased risk of depression and anxiety during early adolescence in males. We found no evidence that adrenarchal hormone levels mediated the sex differences in depression and anxiety.

Journal of Affective DisordersVol. 397
Royal Children's Hospital (AU)
Good health and well-being
Openalex Percentile: Top 31%
Hormonal and reproductive studies
DOIOpen Access PDFOpenAlex
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Are sex differences in adolescent depression and anxiety driven by adrenarchal hormones? A causal mediation analysis from a prospective cohort study — Susan M. Sawyer, Nandita Vijayakumar, et al. · Journal of Affective Disorders (2025) | TGRS Research Map | TGRS