miR-652-5p promoter hypermethylation enhances glioblastoma malignancy through the SDC1/TGFβ2/pERBB4 complex via HIF2α-mediated regulation under hypoxia
Under hypoxic conditions, miR-652-5p promoter hypermethylation promotes GBM malignancy via the SDC1/TGFβ2/pERBB4 axis in a HIF2α-dependent manner. Understanding this mechanism may lead to the development of epigenetic treatments and personalized medical approaches to improve patient outcomes.
Authors
- Nan Wu (ORCID: https://orcid.org/0000-0002-9063-4028)
- J Liu
- Pan Wang (ORCID: https://orcid.org/0000-0001-7340-5082)
- Hui Yao (ORCID: https://orcid.org/0000-0002-7800-0858)
- Sheng Gong
- Bin Liao
- Lu Zhao
Institutions
- Chongqing University (CN)
- Chongqing Emergency Medical Center (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1186/s12935-025-04122-0
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China